Biostatistics Center

The Biostatistics Center is the primary resource for providing biostatistical collaboration and support for biomedical researchers throughout the UConn Health Center and CICATS. Our goal is to provide support for grant development that leads to externally funded grants, ongoing research collaboration, publications, and translational discoveries. Center staff consult with researchers to identify best analysis strategies, study design and power analysis. We are available to investigators in all phases of their research within the UConn community.

  • Provide support for grant development that leads to ongoing research collaboration
  • Help developing a statistical plan
  • Power analysis and sample size
  • Complete "Statistical Considerations" section
  • Biosketch if listed as a Co-Investigator
  • Consult with researchers on optimal study design
  • Offer classes through the Masters in Clinical and Translational Research program
  • Monthly biostatistics journal club
  • Advising for students and physician-scientists in training
  • Mentoring

James Grady, Dr.P.H.
Director, Biostatistics Center

Chia-Ling Kuo, Ph.D.

Rong Wu, M.S., Ph.D.
Research Associate II


Since its inception in 2011, the CICATS Biostatistics Center has collaborated on over 100 grant applications and co-authored over 60 peer reviewed manuscripts with UConn faculty. Below is a current list of our co-authored publications.


Drew DA, Mo A, Grady JJ, Stevens RG, Levine JB, Brenner BM, Anderson JC, Forouhar F, O'Brien MJ, Devers TJ, Rosenberg DW. Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and are Primed for Neoplastic Progression. Mol Cancer Res. 2017 Dec 8. pii: molcanres.0380.2017. doi: 10.1158/1541-7786.MCR-17-0380. [Epub ahead of print] PMID: 29222172

Steffens DC, Wu R, Grady JJ, Manning KJ. Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study. Int Psychogeriatr. 2017 Dec 4:1-6. doi: 10.1017/S1041610217002551. [Epub ahead of print] PMID: 29198213

Nakanishi M, Hanley MP, Zha R, Igarashi Y, Hull MA, Mathias G, Sciavolino F, Grady JJ,  Rosenberg DW. A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice. Carcinogenesis. 2017 Dec 1. doi: 10.1093/carcin/bgx136. [Epub ahead of print]

Mather JF, Corradi JP, Waszynski C, Noyes A, Duan Y, Grady J, Dicks R. Statin and Its Association With Delirium in the Medical ICU. Crit Care Med. 2017 Sep;45(9):1515-1522. doi: 10.1097/CCM.0000000000002530. PMID: 28622167

Wu Z, Barry L, Duan Y, Bohannon R, Covault JM, Grady JJ. Acute Effects of Moderate Alcohol Consumption on Postural Stability in Older Adults.   Percept Mot Skills. 2017 Oct;124(5):912-931. doi: 10.1177/0031512517721069. Epub 2017 Jul 20. PMID: 28728460

Salber GJ, Wang YB, Lynch JT, Pasquale KM, Rajan TV, Stevens RG, Grady JJ, Kenny AM. Metformin Use in Practice: Compliance With Guidelines for Patients With Diabetes and Preserved Renal Function. Clin Diabetes. 2017 Jul;35(3):154-161. doi: 10.2337/cd15-0045. PMID: 28761217

Babapoor S, Wu R, Kozubek J, Auidi D, Grant-Kels JM, Dadras SS. dentification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. Lab Invest. 2017 Jun;97(6):636-648. doi: 10.1038/labinvest.2017.5. Epub 2017 Feb 20. PMID: 28218741

Bidra AS, Zapata G, Agar JR, Taylor TD, Grady J.  Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population. Part 1: Objective Analysis. J Prosthodont. 2017 May 31. doi: 10.1111/jopr.12614. [Epub ahead of print] PMID: 2856126

Roy B, McCullough LD, Dhar R, Grady J, Wang YB, Brown RJ. Comparison of Initial Vasopressors Used for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage. Cerebrovasc Dis. 2017;43(5-6):266-271. doi: 10.1159/000458536. Epub 2017 Mar 21.  PMID: 28319954

Datta D, Foley RJ, Wu R, Grady J, Scalise P. Renal Function, Weaning, and Survival in Patients With Ventilator-Dependent Respiratory Failure. J Intensive Care Med. 2017 Jan 1:885066617696849. doi: 10.1177/0885066617696849. [Epub ahead of print] PMID:28288543

Hoag JR, Kuo CL (2017). Chapter 3: Normal and non-normal data simulations for the evaluation of twosample location tests. Monte Carlo Simulation-Based Statistical Modeling. Springer Singapore, 41-57.

Oncken C, Ricci KA, Kuo CL, Dornelas E, Kranzler HR, Sankey HZ (2017). Correlates of electronic cigarettes use before and during pregnancy. Nicotine Tob Res, 19 (5), pp.585-590.

Andrews R, Chamberlin KW, Ingrassia J, Kuo CL, Pizzi A, Wolf JM. (2017) 5 step guide to conversations between trainees and patients in pain: educating trainees about discontinuing opioids using a staged approach. J Family Med Community Health 4 (5): 1123.

Bidra AS, Nguyen V, Manzotti A, Kuo CL (2017). Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population Part 3: Unblinded and Discriminatory Subjective Analysis. J Prosthodont (in press).

DambskaM, Labrador EB, Kuo CL, Weinstein DA (2017). Prevention of complications in glycogenstorage disease type Ia with optimization of metabolic control. Pediatr Diabetes, 18 (5):327-331.

Lyapis A, Ulrich A, LaMonica R, Kuo CL, Kaye L, Luciano D. (2017). Does the difference in fascial closure technique affect post-operative pain? J Minim Invasive Gynecol, 24 (7), 1190-1194.

Zhou W, Liu Z, Song L, Kuo CL, Shafer DM (2017). Clinical factors affecting the accuracy of guided implant surgery-a systematic review and meta-analysis. J Evid Based Dent Pract.

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Freathy RM, Wood AR, Murray A, Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. (2017). Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers. PLoS One.

Townsel C, Keller R, Kuo CL, Campbell WA, Hussain N (2017). Racial/ethnic disparities in morbidity and mortality for preterm neonates admitted to a tertiary neonatal intensive care unit. J Racial Ethn Health Disparities.

Chhibber A, Agarwal S, Yadav S, Kuo CL, Upadhyay M (2017). Which orthodontic appliance is best for oral hygiene? A randomized clinical trial. Am J Orthod Dentofacial Orthop.

Pilling LC, Kuo CL, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D (2017). Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging.

Moy BT, Forouhar F, Kuo CL, Devers TJ (2017). Endoscopic features of mucous cap polyps during colonoscopy: A retrospective study predicting serrated polyps. Clin Endosc.

Curry EJ, Ke K, Chorsi MT, Wrobel KS, Miller III AN, Patel A, Kim I, Feng J, Yue L, Wu Q, Kuo CL, Lo KW, Laurencin C, Ilies H, Purohit PK, Nguyen TD (2017). Biodegradable piezoelectric force sensor. National Acad Sciences.


Fortinsky RH, Gitlin LN, Pizzi LT, Piersol CV, Grady J, Robison JT, Molony S. Translation of the Care of Persons with Dementia in their Environments (COPE) intervention in a publicly-funded home care context: Rationale and research design. Contemp Clin Trials. 2016 Jul;49:155-65. doi: 10.1016/j.cct.2016.07.006. Epub 2016 Jul 6. PMID: 27394383

Datta D, Foley R, Wu R, Grady J, Scalise P. Can Creatinine Height Index Predict Weaning and Survival Outcomes in Patients on Prolonged Mechanical Ventilation After Critical Illness?. J Intensive Care Med. 2016 May 13;PubMed PMID: 27179057

Santos J, Jones S, Wakefield D, Grady J, Andemariam B. Patient Controlled Analgesia for Adults with Sickle Cell Disease Awaiting Admission from the Emergency Department. Pain Res Manag. 2016;2016:3218186. doi: 10.1155/2016/3218186. Epub 2016 Mar 29. PMID:27445606

Silver E, Wu R, Grady J, Song L. Knot Security- How is it Affected by Suture Technique, Material, Size, and Number of Throws? J Oral Maxillofac Surg. 2016 Jul;74(7):1304-12. doi: 10.1016/j.joms.2016.02.004. Epub 2016 Feb 18.

Works T, Jones S, Grady JJ, Andemariam B. Traumatic Exposure History as a Risk Factor for Chronic Pain in Adult Patients with Sickle Cell Disease. Health Soc Work. 2016 Feb;41(1):42-50. PMID: 26946885

Babapoor S, Horwich M, Wu R, Levinson S, Gandhi M, Makkar H, Kristjansson A, Chang M, Dadras SS. microRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis. Mod Pathol. 2016 May;29(5):461-75. doi: 10.1038/modpathol.2016.44. Epub 2016 Feb 26.

Drew DA, Goh G, Mo A, Grady JJ, Forouhar F, Egan G, Swede H, Rosenberg DW, Stevens RG, Devers TJ. Colorectal polyp prevention by daily aspirin use is abrogated among active smokers. Cancer Causes Control. 2016 Jan;27(1):93-103. doi: 10.1007/s10552-015-0686-1. Epub 2015 Oct 28. PMID:26510933

Salman M, Pike D, Wu R, Oncken C. Effectiveness and Safety of a Clinical Decision Rule to Reduce Repeat Ionized Calcium Testing: a PRE/POST Test Intervention. Connecticut Medicine.2016 Jan: 80(1): 5-10

Naples JG, Spiro J, Tessema B, Kuwada C, Kuo CL, Brown SM (2016). Neck recurrence and mortality in esthesioneuroblastoma: Implications for management of the N0 neck. Laryngoscope, 126: 1373-9.

Bidra AS, Farrell K, Burnham D, Dhingra A, Taylor TD, Kuo CL (2016). Prospective cohort pilot study of 2-visit CAD/CAM monolithic complete dentures and implant-retained overdentures: Clinical and patientcentered outcomes. J Prosthet Dent. 115: 578-586.

Carpinnello OJ, Casson PR, Kuo CL, Raj RS, Sills ES, Jones CA (2016). Costimplications for subsequent perinatal outcomes after IVF stratified by number of embryos transferred: A five year analysis of Vermont data. Appl Health Econ Health Policy, 14: 387-95.

Hoag JR, Kuo CL (2016). Ranking question designs and analysis methods. J Med Stat Inform, 4: 6.

Gohil SV, Kuo CL, Adams DJ, Maye P, Rowe DW, Nair LS (2016). Evaluation of the donor cell contribution in rhBMP2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice. J Biomed Mater Res A, 104: 928-41.


Steffens DC, Manning KJ, Wu R, Grady JJ, Fortinsky RH, Tennen HA. Methodology and preliminary results from the neurobiology of late-life depression study. Int Psychogeriatr. 2015 Dec;27(12):1987-97

Steffens DC, Manning KJ, Wu R, Grady JJ, Fortinsky RH, Tennen HA. Methodology and preliminary results from the neurobiology of late-life depression study. Int Psychogeriatr. 2015 Sep 1:1- [Epub ahead of print]

Wu, Z.H., Stevens R., Tennen H., North C.S., Grady J.J.,  Holzer, C.. Sleep quality among low income young women predicts changes in perceived stress before and after Hurricane Ike in Southeast Texas. Sleep, 2015 Jul 1;38(7):1121-8. doi: 10.5665/sleep.4826.

Hoag J., Grady J.J., Wu, Z.H. Childhood trauma predicting sleep status during a natural disaster in a sample of young, low-income women,  Sleep & Health, 2015, 293-299

Works, T., Jones. S., Grady, JJ, Andemariam, B. Traumatic Exposure History as a Risk Factor for Chronic Pain in Adult Patients with Sickle Cell Disease. Health & Social Work, 2015; doi: 10.1093/hsw/hlv085


Babapoor S, Fleming E, Wu R, Dadras SS. A novel miR-451a isomiR, associated with amelanotypic phenotype, acts a tumor suppressor in melanoma by retarding cell migration and invation. PLoS One. 2014 Sep 19;9(9):e107502

Yang, T., Shen, J.-B., Yang, R., Redden, J., Dodge-Kafka, K., Grady, J.J., Jacobson, K.A.b, Liang, B.T. Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure  Circulation: Heart Failure, Volume 7, Issue 3, May 2014, Pages 510-518 PMID: 24622244

Andemariam B, Owarish-Gross J, Grady JJ, Boruchov D, Thrall RS, Hagstrom JN. Identification of risk factors for an unsuccessful transition from pediatric to adult sickle cell disease care. Pediatr Blood Cancer. Volume 61, Issue 4, April 2014, Pages 697-701, PMID: 24347402

Albertsen, P.C., Klotz, L., Tombal, B., Grady, J.J., Olesen, T.K., Nilsson, J. Cardiovascular morbidity associated with gonadotropin releasing hormone agonists and an antagonist.  European Urology, Volume 65, Issue 3, March 2014, Pages 565-573, PMID: 24210090

Gurram, P., Benn, P., Grady, J.J., Prabulos, A.M., and Campbell, W. First Trimester Aneuploidy Screening Markers in Women with Pre-Gestational Diabetes Mellitus. J. Clin. Med. 2014, 3(2), 480-490; doi:10.3390/jcm3020480


Farrokhi V, Nemati R, Nichols FC, Yao X, Anstadt E, Fujiwara M, Grady JJ, Wakefield D, Castro W, Donaldson J, and Clark RB.  Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis. Clinical & Translational Immunology (2013) 2, e8; doi:10.1038/cti.2013.11  Published online 15 November 2013

Martin KS, Wu R, Wolff M, Colantonio AG, Grady J. A novel food pantry program: food security, self-sufficiency, and diet-quality outcomes. Am J Prev Med. 2013 Nov;45(5):569-75.

Kozubek J, Ma Z, Fleming E, Duggan T, Wu R, Shin DG, Dadras SS. In-depth characterization of microRNA transcriptome in melanoma. PLoS One. 2013 Sep 4;8(9):e72699.

Drew DA, Devers T, Horelik N, Yang S, O'Brien M, Wu R, Rosenberg DW. Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Proteomics. 2013 May;13(9):1428-36.


Duan F, Simeone S, Wu R, Grady J, Mandoiu I, Srivastava PK. Area under the curve as a tool to measure kinetics of tumor growth in experimental animals. J Immunol Methods. 2012 Aug 31;382(1-2):224-8. Epub 2012 Jun 12.